elegans of cellular pathways that govern aging, it hasn't been clear how these pathways interact," said Hermann Haller, M.D., president of the MDI Biological Laboratory. But instead, its lifespan was amplified by 500 percent.
Because alteration of the IIS pathways yields a 100 percent increase in lifespan and alteration of the TOR pathway yields a 30 percent increase, the double mutant would be expected to live 130 percent longer. The new research uses a double mutant in which the insulin signaling (IIS) and TOR pathways have been genetically altered. The discovery of the synergistic effect opens the door to even more effective anti-aging therapies. A number of drugs that extend healthy lifespan by altering these pathways are now under development. elegans, which is a popular model in aging research because it shares many of its genes with humans and because its short lifespan of only three to four weeks allows scientists to quickly assess the effects of genetic and environmental interventions to extend healthy lifespan.īecause these pathways are "conserved," meaning that they have been passed down to humans through evolution, they have been the subject of intensive research. The research draws on the discovery of two major pathways governing aging in C. The increase in lifespan would be the equivalent of a human living for 400 or 500 years, according to one of the scientists.
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